CBRE is to seek a tenant for part of the ground floor of the retail premises at 14-18 Aston Quay in Dublin.
The unit extends to 157sq m (1,686sq ft) and was rented for a period by Boots Chemist.
Adjoining traders include Supervalu, Soho Café and Crunch Fitness.
Niamh Sheehan of CBRE said the unit presented a strong trading opportunity for both retail and restaurant operators seeking a high footfall location in the city centre.