The Cincinnati Bengals ended New England's unbeaten start to the season and Tom Brady's run of 52 games with a touchdown pass as they beat the Patriots 13-6 in Sunday NFL action.
BenJarvus Green-Ellis scored the game’s only touchdown with a one-yard run in the fourth quarter, before Adam Jones intercepted Brady inside the five-yard line with 16 seconds left.
It was the first game without a touchdown for New England since September 20, 2009 – a 16-9 loss to the New York Jets.
The Kansas City Chiefs kept their perfect start alive but made hard work of it in a 26-17 victory over the Tennessee Titans.
Jamaal Charles scored a one-yard touchdown in the fourth quarter to clinch it after the Chiefs had seen a 13-0 half-time lead evaporate in the face of 17 unanswered points from the Titans.
However, the Seattle Seahawks joined New England in suffering a first loss of the season as they blew a 12-0 lead to lose 34-28 to the Indianapolis Colts.
Donald Brown scored the go-ahead touchdown with 8:55 remaining, while Andrew Luck threw for two touchdowns.
Drew Brees threw two touchdown passes to help keep New Orleans' perfect start going with a 26-18 victory over the Chicago Bears.
Both of those passes went to Pierre Thomas, while Jimmy Graham tied an NFL record with a fourth consecutive 100-yard game for a tight end, making 10 catches for 135 yards.
The St Louis Rams needed to get out of a rut and a visit from the winless Jacksonville Jaguars did the trick as Sam Bradford threw three touchdown passes in a 34-20 victory.
Austin Pettis had two touchdown catches as the Rams picked up their second win of the season.
The Green Bay Packers beat the Detroit Lions 22-9 as Mason Crosby kicked five field goals, while Justin Tucker's 44-yard field goal made the difference as the Baltimore Ravens edged the Miami Dolphins 26-23.
The New York Giants' winless start to the season continued as the Philadelphia Eagles overcame the loss of Michael Vick to injury to beat them 36-21 in East Rutherford.
Nick Foles had two fourth-quarter touchdown passes after Vick left the game with a hamstring injury in the second quarter.
Eli Manning was intercepted three times in the fourth quarter as Philadelphia shut down any attempt at a New York fightback.
Payton Manning threw for 414 yards and four touchdowns as the Denver Broncos edged the Dallas Cowboys 51-48 in a high-scoring affair.
Cowboys quarterback Tony Romo was also in fine form as he launched five touchdown passes for 506 yards in the first 500-yard passing game in franchise history.
But the glory went to Matt Prater who kicked a 28-yard field goal as the clock ran down to seal the win and maintain Denver’s perfect start to the season.
The Arizona Cardinals easily overcame a sluggish Carolina offence as they claimed a 22-6 win.
The Panthers could only manage two field goals as Carson Palmer threw to Jim Dray for a single Cards touchdown with Rashard Mendenhall also scoring on a drive.
Matt Schaub was intercepted three times as the Houston Texans offence failed to fire in a 34-3 defeat to the San Francisco 49ers.
Tremaine Brock returned one of those interceptions for a score while Frank Gore, Anthony Dixon and Vernon Davis also scored touchdowns as San Francisco claimed a third win of the season.
Two touchdown passes in the first quarter from Terrelle Pryor and an NFL record-tying 13th defensive touchdown from Charles Woodson helped the Oakland Raiders beat San Diego Chargers 27-17.
