Saturday
Everton (8) v West Brom (20), 12.30pm – Live BT Sport 1
Everton are down to just two fit centre backs after Jarrad Branthwaite was ruled out for up to five weeks with an ankle injury. With Mason Holgate already sidelined by a toe problem which could keep him out until the end of October manager Carlo Ancelotti is left with just Michael Keane and Yerry Mina for the positions in central defence.
Midfielder Alex Iwobi is back in contention after a minor knock but Ancelotti, who made 10 changes for the midweek win over Salford, is likely to recall all his first-choice players including the likes of James Rodriguez, Allan and Abdoulaye Doucoure.
Matt Phillips and Conor Townsend could be in West Brom’s Premier League squad for the first time this season. Both players missed the opening-day defeat to Leicester – Phillips with a back injury and Townsend due to an ankle problem – but they each featured against Harrogate in midweek in the Carabao Cup. Baggies boss Slaven Bilic has signed young midfielder Conor Gallagher on loan from Chelsea in time for the match on Saturday but fellow new recruit Branislav Ivanovic is still building up his fitness. Ahmed Hegazi (hamstring) and Kenneth Zohore (calf) remain doubts.
Last season: No corresponding fixture
Last five league matches: Everton L D W L W; West Brom D D L D L
Match odds: H 52-100 A 11-2 D 16-5
Referee: Mike Dean
Leeds (13) v Fulham (19), 3pm – Live BT Sport 1
Leeds captain Liam Cooper is hoping to make his first appearance of the season. Cooper missed the opening-day defeat at Liverpool and the midweek Carabao Cup exit to Hull, but is fit to return after a calf injury. Marcelo Bielsa, who has no new injury worries, will revert back to his strongest line-up after making 11 changes on Wednesday night. Bielsa confirmed club record signing Rodrigo, who made his first start against Hull, will be among the substitutes.
Fulham boss Scott Parker has no new injury concerns. France goalkeeper Alphonse Areola, Dutch full back Kenny Tete and United States defender Antonee Robinson could all make their Premier League debuts after featuring in the Carabao Cup win at Ipswich in midweek.
Former Chelsea full-back Ola Aina is in line for his first appearance since joining Fulham on a season-long loan deal from Torino.
Last season: No corresponding fixture
Last five league matches: Leeds W W W W L; Fulham W D W D L
Match odds: H 8-13 A 9-2 D 3-1
Referee: Anthony Taylor
Manchester United (12) v Crystal Palace (7), 5.30pm – Sky Sports
Donny van de Beek is in line to make his Manchester United debut. The Dutch international – the only summer signing to date – will play a role on Saturday evening, when manager Ole Gunnar Solskjær says Paul Pogba (coronavirus) and Luke Shaw (ankle) will be available. Phil Jones (knee), Axel Tuanzebe (foot) and Sergio Romero (extended holiday) are unavailable for Solskjær, who refused to confirm whether Dean Henderson or David De Gea would start in goal.
Crystal Palace boss Roy Hodgson is set to keep faith with the team which earned an opening-day victory over Southampton. The Eagles made 10 changes for the midweek Carabao Cup clash at Bournemouth, with only Jeffrey Schlupp starting from the weekend win, as they looked to avoid any more injuries. Palace remain without Nathan Ferguson (knee), Gary Cahill, James Tomkins (both hamstring) and Patrick Van Aanholt (shoulder), but Mamadou Sakho, Jairo Riedewald, Christian Benteke and Connor Wickham have returned to fitness although are not deemed match-fit.
Last season: Crystal Palace 0 Man Utd 2, Man Utd 1 Crystal Palace 2
Last five league matches: Man Utd W D W D W; Crystal Palace L L L D W
Match odds: H 3-10 A 10-1 D 17-4
Referee: Martin Atkinson
Arsenal (1) v West Ham (18), 8pm – Live Sky Sports
Arsenal defender David Luiz is fit for the visit of London rivals West Ham. The Brazilian missed the opening day win over Fulham due to a neck spasm but is now in contention to face the Hammers. Sokratis Papastathopoulos (calf), Pablo Mari (ankle), Shkodran Mustafi (hamstring), Emile Smith Rowe (shoulder), Calum Chambers and Gabriel Martinelli (both knee) are all still missing while William Saliba waits to make his debut.
West Ham will check on the fitness of captain Mark Noble after he missed training on Friday with a toe injury. The midfielder has had an injection and boss David Moyes will hope to have him available. Jack Wilshere is also back in training after an ankle injury but is not expected to start against his old club.
Last season: Arsenal 1 West Ham 0, West Ham 1 Arsenal 3
Last five league matches: Arsenal L W L W W; West Ham W W D D L
Match odds: H 8-15 A 5-1 D 10-3
Referee: Michael Oliver
Sunday
Southampton (14) v Tottenham (15), 12pm – Live BT Sport
Nathan Redmond is expected to miss out for Southampton due to an ankle ligament injury. Saints winger Redmond suffered the problem during Wednesday evening's 2-0 Carabao Cup loss at home to Championship club Brentford. Midfielder Stuart Armstrong could return to Ralph Hasenhüttl's squad having resumed training following a thigh injury, while summer signing Mohammed Salisu is building fitness as he awaits his Saints debut.
Tottenham will assess their squad after their gruelling Europa League trip to Bulgaria on Thursday night. José Mourinho should be able to freshen things up if he needs to after leaving eight players at home, with Dele Alli and Toby Alderweireld among those who did not travel. Japhet Tanganga is out with a thigh injury, but Serge Aurier will hope to shake off a training knock.
Last season: Southampton 1 Tottenham Hotspur 0, Tottenham Hotspur 2 Southampton 1
Last five league matches: Southampton D D W W L; Tottenham Hotspur W W W D L
Match odds: H 11-5 A 13-10 D 23-10
Referee: David Coote
Newcastle (4) v Brighton (16), 2pm – Live Sky Sports
Newcastle head coach Steve Bruce will turn to his big guns once again. Bruce made 10 changes for Tuesday night's somewhat fortuitous 1-0 Carabao Cup second round victory over Blackburn and while defender Ciaran Clark, midfielder Matt Ritchie and summer signing Ryan Fraser got important game-time under their belts, he is likely to revert to the bulk of the men who started last Saturday's 2-0 league win at West Ham. Striker Yoshinori Muto has joined Spanish club Eibar on a season-long loan deal, while keeper Martin Dubravka (ankle), defender Paul Dummett (tendon), defender Fabian Schär (shoulder), midfielder Matty Longstaff (thigh) and striker Dwight Gayle (knee) are still out.
Brighton will hand late fitness tests to Adam Lallana and Ben White ahead of the trip to St James’ Park. Midfielder Lallana limped out of his Albion debut against Chelsea on Monday evening, while defender White had his first top-flight appearance cut short by an ankle problem. Goalkeeper Christian Walton (ankle) and long-term absentees Florin Andone and Jose Izquierdo remain unavailable to Albion boss Graham Potter.
Last season: Brighton 0 Newcastle 0, Newcastle 0 Brighton 0
Last five league matches: Newcastle L L D L W; Brighton L D D W L
Match odds: H 8-5 A 9-5 D 11-5
Referee: Kevin Friend
Chelsea (3) v Liverpool (6), 4.30pm – Live Sky Sports
Hakim Ziyech, Ben Chilwell and Thiago Silva will all miss out for Chelsea. The new recruits must wait for their league debuts for the Blues, with Ziyech still nursing a knee complaint, Chilwell a heel issue and Silva searching for match fitness. Christian Pulisic is still to shake off a hamstring problem, but striker Timo Werner is fit, having eased past a dead leg picked up at Brighton on Monday.
Liverpool manager Jürgen Klopp will have to wait to give Thiago Alcantara his debut as the signing of the Bayern Munich midfielder was not completed in time. Klopp, however, has had a full week of preparations and reported no new injury worries after Saturday’s thrilling win over Leeds. Klopp is likely to name the same matchday squad, although Fabinho is set to return to starting line-up at the expense of Naby Keita.
Last season: Liverpool 5 Chelsea 3, Chelsea 1 Liverpool 2
Last five league matches: Chelsea L W L W W; Liverpool D L W W W
Match odds: H 11-5 A 6-5 D 13-5
Referee: Paul Tierney
Leicester (2) v Burnley (10), 7pm – Live BBC One
Jonny Evans remains out for Leicester as he serves the second of his three-game ban. James Maddison was fit enough make the bench in Sunday's 3-0 win at West Brom after recovering from a hip injury and will be assessed over whether he can start. Wes Morgan is available after returning to training, Filip Benkovic remains out and Ricardo Pereira is over a month away from returning from an Achilles injury.
Burnley defender James Tarkowski is being assessed after missing Thursday’s Carabao Cup tie against Sheffield United with a toe problem. Johann Berg Gudmundsson is unavailable having sustained medial ligament damage in his knee during the tie. Ben Mee (thigh) and Jack Cork (ankle) and Ashley Barnes are out although Barnes is set to feature for the under-23s next week.
Last season: Burnley 2 Leicester 1, Leicester 2 Burnley 1
Last five league matches: Leicester L W L L W; Burnley W D D W L
Match odds: H 13-20 A 9-2 D 14-5
Referee: Lee Mason
